Interesting concept. Good use of the New Madrid, heh, though that might not be as well known nationally as you might think. Kind of a mix of Shadowrun and Johnny Mnemonic (in the class stratification-sense). This could be fun, though we'd have to be careful not to infringe upon other already known properties in doing so. I do see some chance this could clash with Shadowrun especially.
I like the concepts of applying cutting edge science (genetech instead of bioware, etc) to the cyberpunk stories of yore, but much of this genre has been mined previously. I have a couple interesting thoughts, but not sure how far we could take this where it hasn't been taken before. It doesn't inspire me as much as a couple other settings submitted, though I could see having fun with it for a full campaign as opposed to just a couple sessions. Hearkens me back to memories of the Shadowrun Nintendo game, actually... :-)
Writing is topnotch. You definitely get the most out of the content given with clear and good word use.
